2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N9402
    Prosaikogenin A 99365-21-6 99.20%
    Prosaikogenin A is a triterpene saponin isolated from Clinopodium chinense. Prosaikogenin A has significant promoting effects on platelet aggregation with an EC50 value of 12.2 μM.
    Prosaikogenin A
  • HY-N9530
    1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone 120693-53-0 98%
    1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone, a quinolone alkaloid, is a diacylglycerol acyltransferase inhibitor and angiotensin II receptor blocker, with IC50s of 20.1 μM and 34.1 μM, respectively. 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone shows potent anti-Helicobacter pylori activity with the MIC of 10 μg/mL.
    1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone
  • HY-NP176
    Agkistrodon Haemocoagulase 98%
    Agkistrodon Haemocoagulase is a thrombin protein from Agkistrodon that can be used as a hemostatic compound.
    Agkistrodon Haemocoagulase
  • HY-P0038
    MK-852 138199-64-1 98%
    MK-852 (L-367073) is an effective GPIIb/IIIa receptor antagonist. MK-852 can significantly inhibit the binding of fibrinogen to platelets in vitro. MK-852can be used for the study of thrombosis.
    MK-852
  • HY-P0142
    DT-3 329306-46-9 98%
    DT-3 is a membrane-permeable protein kinase G Iα (PKG Iα) inhibitory peptide and shows pharmacological blockade of the cGMP-PKG signalling.
    DT-3
  • HY-P0143
    Leucylarginylproline 133943-59-6 98%
    Leucylarginylproline is an angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 0.27μM.
    Leucylarginylproline
  • HY-P0211
    [Ac-Tyr1,D-Phe2]GRF 1-29, amide (human) 93965-89-0 98%
    [Ac-Tyr1,D-Phe2]GRF 1-29, amide (human), a growth hormone releasing factor (GRF) analogue, is a vasoactive intestinal peptide (VIP) antagonist.
    [Ac-Tyr1,D-Phe2]GRF 1-29, amide (human)
  • HY-P1016
    BQ-3020 143113-45-5 98%
    BQ-3020 is a selective endothelin receptor (ETB receptor) agonist that displaces [125I] ET-1 binding to ETB receptors, with an IC50 value of 0.2 nM. BQ-3020 elicits vasoconstriction in the rabbit pulmonary artery. BQ-3020 makes relaxation of the pig urinary bladder neck and can be used for cardiovascular disease research12.
    BQ-3020
  • HY-P1017
    MDL 29913 135721-56-1 98%
    MDL 29913, a cyclic pseudopeptide, is a competitive NK2 tachykinin receptor selective antagonist, with a pA2 of 8.66.
    MDL 29913
  • HY-P1019
    [Ala1,3,11,15]-Endothelin (53-63) 121204-87-3 98%
    [Ala1,3,11,15]-Endothelin (53-63) is an ETB agonist. [Ala1,3,11,15]-Endothelin (53-63) has selectivity for ETB with IC50 values range from 0.33 nM to 0.61 nM. [Ala1,3,11,15]-Endothelin (53-63) can be used for the research of vasoconstriction
    [Ala1,3,11,15]-Endothelin (53-63)
  • HY-P1100
    PM102 1234564-95-4 98%
    PM102 (HepArrest) is a heparin antagonist that can reverses the anticoagulant effect of heparin. PM102 potently binds heparin (Kd = 36 nM) in vitro.
    PM102
  • HY-P1163
    D[LEU4,LYS8]-VP 42061-33-6 98%
    D[LEU4,LYS8]-VP is a selective agonist of vasopressin V1b receptor, with the Kis of 0.16 nM, 0.52 nM, and 0.1.38 nM for rat, human and mouse V1b receptor, respectively. D[LEU4,LYS8]-VP has weak antidiuretic, vasopressor, and in vitro oxytocic activities.
    D[LEU4,LYS8]-VP
  • HY-P1164
    Urotensin II (114-124), human 251293-28-4 98%
    Urotensin II (114-124), human, an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14.
    Urotensin II (114-124), human
  • HY-P1166
    UFP-803 879497-82-2 98%
    UFP-803 is a potent urotensin-II receptor (UT) ligand. UFP-803 has lower residual agonist activity, so it may be an important tool for the investigations on the role played by the UT system in physiology and pathology.
    UFP-803
  • HY-P1167
    [Orn5]-URP 782485-03-4 98%
    [Orn5]-URP is a potent and selective pure antagonist of Urotensin-II receptor (UT), with an pEC50 of 7.24. [Orn5]-URP displays no agonist activity.
    [Orn5]-URP
  • HY-P1181
    Pam2CSK4 868247-72-7 98%
    Pam2CSK4 is a TLR2 agonist. Pam2CSK4 induces the expression of iNOS and NO in macrophage cell lines via TBK1 and MyD88 molecules. Pam2CSK4 activates the NF-κB and Bruton's tyrosine kinase signaling pathways in platelets, and promotes platelet-endothelial cell interactions. TLR2 activation triggered by Pam2CSK4 expands myeloid-derived suppressor cells (MDSCs) and suppresses anti-tumor immune responses in the tumor microenvironment. Pam2CSK4 acts as a Th2-polarizing adjuvant in mouse vaccine models against Leishmania major and Brugia malayi. Pam2CSK4 can be used in the research of various diseases, including thromboinflammatory diseases, sepsis, atherosclerosis, heart failure, influenza, lymphoma, melanoma, cutaneous leishmaniasis and lymphatic filariasis.
    Pam2CSK4
  • HY-P1184
    HNGF6A 1093111-54-6 98%
    HNGF6A is a humanin analogue. HNGF6A increases glucose-stimulated insulin secretion and glucose metabolism, and has the potential for diabetes research. HNGF6A inhibits of ROS production during oxidative stress. HNGF6A can prevent endothelial dysfunction and atherosclerosis in vivo.
    HNGF6A
  • HY-P1196
    Kisspeptin 234 1145998-81-7 98%
    Kisspeptin 234, is a 10 amino acid peptide as well as a kisspeptin receptor (KISS1, GPR54) antagonist. Kisspeptin 234 is an analog of Kisspeptin 10.
    Kisspeptin 234
  • HY-P1261
    Parstatin(mouse) 1065756-01-5 98%
    Parstatin(mouse), a cell-penetrating PAR-1 thrombin receptor agonist peptide, is a potent inhibitor of angiogenesis.
    Parstatin(mouse)
  • HY-P1262
    Parstatin(human) 1065755-99-8 98%
    Parstatin(human), a cell-penetrating PAR-1 thrombin receptor agonist peptide, is a potent inhibitor of angiogenesis.
    Parstatin(human)
Cat. No. Product Name / Synonyms Application Reactivity